Opinion : Letter to the Editor: Gingrich on Controversial Treatment

Dear Editor:

To Norma Gould and others:

Did you click on the link to Democrat State Senator Karen Whitsett? The drug therapy you state is unproven, but I don't think it matters much to those who are out of choices. Medicos are starting to think that when a patient is put on a ventilator that it may not be the appropriate therapy. An article I read just a few days ago suggests that when the oxygen exchange rate goes to the point where a ventilator is used that within hours or perhaps a few days the O2 exchange rate may not improve or worsens. Other tragic events can occur such as the heart muscle weakening to the point where clots may form in the brain (stroke) and/or lungs (pulmonary embolism) further complicating things is due to the heart weakening kidney function starts to fail. As I have stated many times there may be many therapies that have success. At the moment I have heard of only two - One is the hydroxychloroquine/ Azithromycin plus zinc the other is a drug therapy using a common vitamin - vitamin C. Both therapies reduce inflammation which in many patients happens when the autoimmune system overreacts to the virus (inflammation) causing fluid to accumulate in the lungs (pneumonia). As Governor Cuomo of New York stated 80% of those on ventilators do not recover. Fox medical contributor Dr. Janette Nesheiwat has stated the failure rate is as high as 88%. These are not good odds. So then it seems logical that drug therapy either Vit C or hdq has a higher success rate than a ventilator. Here is the link to the Michigan lawmaker again - view it before you slander me again.

https://nypost.com/2020/04/07/michigan-democrat-says-hydroxychloroquine-saved-her-life/

From Newt Gringrich's newsletter.Thus: East Virginia Medical School

"Seven U.S. physicians have joined together to promote a controversial treatment for seriously ill COVID-19 patients. As the death toll mounts in a desperate struggle against the virus, they are urging hospitals everywhere to try their strategy - one they believe saves lives and reduces dependence on increasingly scarce ventilators.

The physicians, who jointly established the "Front Line COVID-19 Critical Care Consortium," recommend a treatment that primarily involves the intravenous combination of vitamin C and corticosteroids. The protocol calls for the treatment to start as soon as a patient enters the emergency room and continue every six hours during the course of the illness.

Paul Marik, MD, Professor of Internal Medicine and Chief of Pulmonary and Critical Care Medicine at EVMS, conceived of the treatment as a way to battle runaway inflammation in the lungs - the real killer in most COVID-19 patients.

"It's not the virus that's killing the host, it's the host's response to the virus," Dr. Marik says, describing the excessive levels of inflammation that result from an overly aggressive immune system.

The immune system responds to an infection by releasing proteins known as cytokines that initiate inflammation. Inflammation is a natural part of the healing process, but an overreactive immune system can trigger a "cytokine storm" that can send inflammation spiraling to dangerous levels.

When this extreme inflammation leaves patients short of breath, caregivers mistakenly attribute it to acute respiratory distress syndrome (ARDS), Dr. Marik says. The standard ARDS treatment is intubation - inserting a tube down the throat and directly into the lungs - and connecting them to a mechanical ventilator that forces air into the lungs. Unfortunately, a large majority of ventilated COVID-19 patients - in some cases more than 80 percent - are dying.

To avoid ventilation, Dr. Marik and his colleagues cool the overheated immune system with vitamin C and steroids, both strong anti-inflammatory molecules. They are particularly effective when used in combination.

Joseph Varon, MD, Professor of Acute and Continuing Care at the University of Texas Health Science Center and Chief of Staff/Chief of Critical Care at United Memorial Medical Center in Houston, Texas, has come to depend on the combination treatment.

"You start it early and patients don't even need to be intubated," Dr. Varon says in a YouTube video just released by the consortium. At last count, he had no deaths among 24 patients treated with vitamin C and steroids.

Dr. Marik reiterates the importance of starting the treatment early.

"If you wait for them to crash and you wait for them to end up on a ventilator, the Titanic is already sinking," Dr. Marik says. "You have to intervene early and aggressively to prevent them from deteriorating."

The vitamin C/steroid protocol is not widely used in the U.S. because large sectors of the medical community doubt its effectiveness, says consortium member Pierre Kory, MD, Critical Care Service Chief at the University of Wisconsin School of Medicine and Public Health in Madision, Wisconsin.

"Whenever you make a strong claim around a vitamin, I think most doctors are very conservative and skeptical of such claims," Dr. Kory says in the video. "So, it's very hard for most physicians to adopt the therapy fully."

The treatment is controversial but not unconventional. Vitamin C has been used widely in China's treatment of COVID-19 patients, and a clinical trial of high-dose vitamin C is underway there now.

Veteran emergency physician and consortium member Howard Kornfeld, MD, says standard protocols are not working in places like New York. "It's a disaster," he says. "And that disaster is coming to other cities."

Consortium members believe their treatment can help thwart the disaster.

"People are dying needlessly," Dr. Marik says. "This protocol will save lives."

The protocol is available at EVMS.edu/Covidcare."

April 21, 2020 Edition Washington Examiner page 41 Article by Cassidy Morrison - Healthcare Could Provide a Blueprint for Coronavirus Treatments. from New York University Langone Hospital
Quote: " The antimalarial medication most touted by the Trump Administration as possible coronavirus treatments Hydroxychoroquine and its relative Chloroquine led to the greatest number of patients who survived the virus and were able to leave the hospital. About 87.6% of female patients treated with hydroxychloroquine or chloroquine along with the antibiotic azithromycin survived and 87.7% of male patients on the same regimen survived.
The Food And Drug Administration granted emergency use authorization to hydroxychloroquine manufacturers which allows the medication to be 'donated to the Strategic National Stockpile to be distributed and prescribed by doctors' but does not require clinical trials to prove it works."Regards,

John Stiegelmeyer